Home Systems biology Scientists find out why diet and exercise don’t always work

Scientists find out why diet and exercise don’t always work

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A team of American scientists from the Institute for Systems Biology have found that there is a correlation between a person’s ability to lose weight and the genetic characteristics of their gut microbiome, according to a study. published September 14 in mSystems magazine.

The research is based on the observations of 105 people who participated in a wellness program, after which about half of the participants showed consistent weight loss, while another part did not respond to lifestyle changes. At the same time, the data obtained revealed that weight loss in those observed did not depend on his body mass index (BMI).

On the contrary, they found that the microbiome of people who lost weight showed higher growth rates of bacteria, due to genes that divert nutrients to the growth of bacterial cells. For its part, the microbiome of people resistant to weight loss had lower growth rates and he was inclined to break down fiber and starch into absorbable sugars.

According to scientists, the intestinal microbiome plays the role of “Important filter between the food we eat and our blood circulation”, weight loss can therefore be particularly difficult when the gut bacteria show high growth rates.

“At a minimum, this study can lead to diagnoses to identify individuals who will respond well to moderate changes to a healthy lifestyle, and those who may require more drastic measures to achieve weight loss,” said one. study authors Sean Gibbons.

In this sense, he points out that identifying the microbes and metabolic processes that facilitate weight loss will help create prebiotic and probiotic treatments for reduce resistance from the microbiome to weight loss.


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