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Attempts at weight loss not working the way you want them to? Time to pay attention to your gut microbiome, study finds

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The COVID-19 pandemic and its ensuing stay-at-home scenario forced people to once again focus on themselves and choose healthy options over a sedentary lifestyle. Some people have been successful in losing that extra fat, but others have had a little less success. What could be the reason for this discrepancy? While there may be several variables – including eating and training habits – a new study indicates that the genetic capacity of the gut microbiome is also an important factor that influences the weight a person is likely to lose with weight loss. simple lifestyle changes. The gut microbiome, which contains billions of bacteria, fungi, and other microbes, plays a key role in digestion. It also benefits the immune system.

Researchers studied 105 people during a commercial wellness program, which included coaching on a healthy lifestyle. Half of them showed constant weight loss (1 percent of their body weight per month over 6 to 12 months), the other half maintained a stable body mass index (BMI).

The study was published in the open access journal of the American Society for Microbiology mSystems.

Those who lost weight easily had higher rates of bacterial growth in their microbiome. They were also enriched with genes. Those who showed resistance to weight loss had lower rates of bacterial growth and a higher ability to break down nonabsorbable fiber and starches into absorbable sugars, according to the study by researchers at the Institute for Systems Biology. (ISB).

“In this study, we sought to better understand the interactions between baseline BMI, metabolic health, diet, gut microbiome function profiles, and subsequent weight changes in a human cohort that underwent intervention on a healthy lifestyle. Overall, our results suggest that the microbiota may influence the host’s weight loss responses through varying rates of bacterial growth, efficiency of dietary energy harvesting, and immunomodulation ”, said the researchers, led by Dr Christian Diener.

The researchers said they studied factors of successful weight loss that were independent of BMI. People with a higher baseline BMI lose more weight after a procedure. Research has already shown that a change in diet can change the makeup of bacteria in the gut. So, this study shows that if a person’s bacterial genetic makeup is resistant to weight loss, perhaps a change in diet can help.

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